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Finally, since endogenous GLP-1 is involved in the regulation of energy metabolism both in the periphery as well as in the brain, compounds acting as GLP-1R agonists can also normalize mitochondrial function, which also appears to be repeatedly disrupted in the depressive brain and thus possibly exacerbate neuroprotective effects, e.g
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In monotherapy clinical trials for migraine prophylaxis, the following effects occurred more frequently with topiramate 50 to 200 mg per day than placebo: fever (1% to 2% vs
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