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A double-blind, randomized controlled trial published in Clinical, Cosmetic and Investigational Dermatology demonstrated that oral glutathione (500 mg daily) taken for 8-12 weeks showed some improvement in melasma severity compared to placebo
What neither camp disputes is the core evidentiary finding: across all seven compounds reviewed over the two days, there are no large, controlled, randomized human trials establishing safety or efficacy for the proposed injectable routes
approval of an ingredient or solution for one use does not establish a beauty claim
If you notice persistent irritation, redness, or any unusual reactions, discontinue use and consult a dermatologist
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