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3.6 Periostin Periostin is a bone turnover-related osteokine that is highly expressed in collagen-rich tissueincluding periosteumand mediates tissue remodeling through binding to integrin receptors and proteoglycans
It first drew research interest for its ability to heal stomach ulcers and inflammatory bowel conditions, then expanded to tendon, ligament, muscle, and even bone healing across dozens of preclinical studies (Sikiric et al., PubMed)
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