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Although -oxidation is impaired in the setting of VPA toxicity, this metabolite has a prolonged elimination half-life and could be responsible for the prolonged coma that is sometimes observed despite the normalization in plasma VPA concentrations [17, 18]
Nutr Rev 54 : 130
Sartorelli & David G
The epidermis also features tight junction proteins that enhance barrier integrity and includes four primary cell types: keratinocytes (forming the water barrier), melanocytes (pigment production), Langerhans cells (immune defense), and Merkel cells (touch receptors) [226, 227]
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