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In the SURMOUNT-1 obesity trial, tirzepatide produced mean weight reductions of roughly 1521% depending on dose over 72 weeks ( Jastreboff et al., NEJM 2022

Acknowledgements The authors thank members of the Zhang laboratory and George Mentis at Columbia University for scientific inputs and helpful discussions during this study, the Columbia Transgenic Mouse Core Facility for producing Ank3 E35a / mice, and the Columbia Neurobehavior Core Facility for assisting with behavior analyses

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