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Glutathione S-conjugates are usually sequestered by distinct ABC transporters from the cytosol into the vacuole for degradation, although breakdown of glutathione, oxidized glutathione and glutathione S-conjugates also happens outside the vacuole 56

the caution applies particularly to inhaled or intravenous NAC, which may occasionally trigger bronchospasm

Pfam domains echo these functions, recovering osmoregulation by neurotransmitter-gated ion channel domains, stimulus and neuronal functions by transmembrane receptor, and detoxification by cytochrome P450 (Fig

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