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Although amylase and lipase levels were numerically higher in the dulaglutide group during follow-up, clinically significant pancreatitis was rare, with only one case observed, likely related to gallstone disease rather than direct pharmacologic toxicity

Some patients report that musculoskeletal discomfort tends to peak during the initial titration phase or periods of rapid weight loss, then gradually diminishes over subsequent weeks to months, though this observation is largely anecdotal and not well-documented in clinical studies