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The study previously reported a 20% relative risk reduction in heart attacks and strokes for those receiving semaglutide compared to placebo over three years
In comparison, a small molecule like orforglipron is a roughly 16-step convergent organic synthesis from common starting materials (see, e.g., Part I and Part II of a key intermediate synthesis from the Lilly process team)
TRANSCEND-T2D-1 reported dysesthesia in 2.34.5% of participants
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