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Rheumatoid arthritis, lupus, and multiple sclerosis are widespread autoimmune diseases characterised by chronic inflammation and an overactive immune response

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Deficiency is particularly common in elderly people, because the ability to absorb vitamin B12 can decrease with age ( Other people at risk of deficiency include those who have had intestinal surgery, including weight loss surgery

5-Amino-1MQ instead removes a drain on that route: by inhibiting NNMT it prevents nicotinamide from being methylated to 1-methylnicotinamide, leaving it available for NAMPT and the salvage pathway, and simultaneously spares the S-adenosyl-L-methionine that the methylation would have consumed