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Bacteria secrete membrane vesicles called bacterial extracellular vesicles (bEVs), spherical structures with a lipid bilayer containing various biomolecules from the parent bacterium
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Once inside the cell, Fe 3+ is reduced to Fe 2+ via six-transmembrane epithelial antigen of prostate 3 (STEAP3) and transported into the cytosol by divalent metal transporter 1 (DMT1) and ZRT/IRT-like proteins 8 and 14 (ZIP8/14) (Wang et al., 2025d)
But for patients through age 18 , a separate code set applies when physician or qualified healthcare professional counseling is provided during the immunization encounter
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