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While linker instability is a common characteristic of currently-approved ADCs and may actually contribute to antitumor activity and decreased normal tissue metabolism of ADCs, off-tumor toxicity from payload release in the systemic circulation has been a limiting factor in the development of prostate cancer ADCs, especially PSMA-based ADCs plagued with problems of peripheral neuropathy 6,74
See the KLOW vs GLOW vs Wolverine comparison and the KLOW dosage guide
While Ive stained two or three of my white lab coats in the process, Im excited about methylene blues potential to help as many people as possible
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