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Empty-stomach guideline: Many protocols prefer an empty stomach (often avoiding a meal for ~23 hours beforehand) because large mealsespecially higher carbohydrate or fat intakemay blunt parts of the GH response and make results less consistent

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Quick Answer: GLP-1 receptor agonist-related fatigue likely results from multiple indirect mechanisms including substantial caloric restriction, gastrointestinal side effects causing dehydration and nutritional deficits, and metabolic adaptation during weight loss, rather than a single direct pharmacological effect

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