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Typical titration schedule in trials: Start at 2 mg weekly Increase every 4 weeks: 2 mg 4 mg 6 mg 9 mg or 12 mg (depending on target dose) This means it takes 3-4 months to reach the maximum dose Meaningful weight loss becomes apparent after reaching therapeutic doses and maintaining them for several weeks

The liver has a number of important functions as well as detoxification, and is susceptible to damage, therefore supporting it is paramount to health