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This disulfide/thiol switch is operated by cytosolic Grx2 as modulator/terminator (Brutigam et al., 2011
Raji cells were transiently reverse-transfected with siTNFR1 (50 nM), and the cells were cultured for 72 h
Results therefore highlight the importance of circadian regulation to fundamental cellular functions and support the hypothesis that disruption of core clock genes may lead to cancer development
GSSG sensitized hepatocytes to TNF-mediated cytotoxicity via the induction of IKK- glutathionylation and subsequent NF-B suppression NF-B activation plays a critical role in protecting hepatocytes from TNF-mediated cytotoxicity
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