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PMID: 41811010, DOI: 10.1016/j.jacc.2025.12.043

The researchers also noted that 23.5% (95% CI, 22.3-24.8) of people meeting FDA indications for tirzepatide reported using medications that may slow gastrointestinal motility, which could increase gastrointestinal adverse effects when combined with any GLP-1 receptor agonist