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Methodology: The study authors conducted an exhaustive search through Medline and the Cochrane Library for RCTs assessing the maintenance doses of subcutaneous tirzepatide at 5, 10, or 15 mg once-weekly, or subcutaneous semaglutide at 0.5, 1.0, or 2.0 mg once-weekly, spanning a minimum of 12 weeks

Neurochemically mediated sexual side effects typically resolve within one to two months after discontinuation, as semaglutide clears the system and brain chemistry recalibrates

[2] [3] GIP also augments glucose-dependent insulin secretion, though its effects on appetite and gastric emptying are more context-dependent and may be influenced by co-agonism with GLP-1