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Melanin is responsible for the appearance of dark spots and uneven skin tone
Over time, as patients adjusted to the increased dose, the side effects typically subsided
Within this framework, we critically examine representative nanotherapeutic strategies across pharmacokinetic and biodistribution-oriented design, vascular and stromal normalization, tumor microenvironment-responsive activation, immune priming and intratumoral reprogramming, and clinically relevant theranostic approaches
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