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These medications induce weight loss because they act like GLP-1 in the body and are able to suppress appetite (agonist refers to a drug that binds to a receptor inside a cell or on its surface and causes the same action as the substance that normally binds to the receptor)

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5,7,8 The magnitude of weight loss is a significant factor in the potential benefit of GLP-1RAs in HFpEF patients with obesity