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Ipamorelin activates the ghrelin receptor (GHSR-1a), while CJC-1295 activates the GHRH receptor on the same pituitary somatotroph cells
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However, these treatments may indirectly affect B12 levels through slowed gastric emptying, reduced dietary intake due to appetite suppression, and interaction with concurrent metformin use, which is known to reduce B12 absorption
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