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In a mouse model of chronic IH and sleep fragmentation to simulate the pathological characteristics of OSA, activation of NRF2 by sulforaphane modulates ER stress, protects hippocampal neurons from apoptosis, and reduces the inflammatory response by regulating the expression of the antioxidant gene Prdx1
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For example, SCFAs could influence tryptophan metabolism by promoting the production of AhR ligands, which are known to exert anti-inflammatory effects and enhance mucosal barrier integrity (83)
These recommendations are for the cyanocobalamin form of B12 onlythe form in fortified foods and most supplements
