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Vet Immunol Immunopathol

This pulsatile pattern preserves the negative feedback loop: somatostatin still regulates the system normally between pulses

Exp Ther Med 23:363 Ferrario M, Cambiaghi A, Brunelli L, Giordano S, Caironi P, Guatteri L, Raimondi F, Gattinoni L, Latini R, Masson S, Ristagno G, Pastorelli R (2016) Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach