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It binds the GHRH receptor, a G-protein-coupled receptor whose activation drives both somatotroph proliferation and GH synthesis and secretion [1]
So if we were to inhibit the SLC33A1 transporter, the GSSG would accumulate, and the cancer cells would die. Our work demonstrates that defining how nutrients and metabolites are transported across cellular and organelle membranes reveals fundamental principles of cell biology while uncovering a major class of disease-relevant and therapeutically tractable proteins, Birsoy says
It may come and go, or it may be constant
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