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While senescent cells are often discussed in the context of inflammatory signaling, their accumulation is fundamentally linked to impaired energy metabolism and oxidative stress

doi: 10.1016/j.diabres.2005.11.007 38 JhalaUSCanettieriGScreatonRAKulkarniRNKrajewskiSReedJet al

Without effective transition-of-care strategies, including medication reconciliation, patient education, and timely outpatient follow-up, the benefits of inpatient interventions may be diminished

Aging is associated with GSH deficiency and elevated oxidative stress, and GSH deficiency in older adults occurs due to impaired synthesis rather than increased breakdown