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Within the GLP-1 receptor agonist class , other options available in the UK include: Dulaglutide (Trulicity) weekly injection with proven cardiovascular benefits [12] [17] Liraglutide (Victoza) daily injection with proven cardiovascular benefits [13] Exenatide (Byetta) twice-daily injection Exenatide extended-release (Bydureon) weekly injection Lixisenatide (Lyxumia) daily injection Tirzepatide (Mounjaro) weekly injection that acts on both GLP-1 and GIP receptors [14] [15] Whilst these medications share similar mechanisms to semaglutide, individual tolerability varies
However, its primary mechanism is AMPK activationsimilar to metforminrather than GLP-1 manipulation
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Studies like the STEP trials show that with semaglutide, weight loss tends to slow down and plateau around week 60
