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Furthermore, TSA (a nonspecific HDAC inhibitor) treatment successfully mimicked the effect of NaB on GLP-1R expression in HepG2 cells, and this finding strongly supported the idea that NaB may affect liver GLP-1 sensitivity through HDAC inhibition

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Tumours stained and quantified for TOM20 intensity ( a ) or cleaved Caspase 3 positivity ( b )