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This includes vegans and vegetarians, older adults, individuals with atrophic gastritis, pernicious anemia, gastrointestinal disorders, those who have had gastrointestinal surgery and people who take certain medications including, but not limited to, estrogen (HRT), and birth control pills
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Humans express three malic enzymes, one cytoplasmic that requires NADP + and two mitochondrial enzymes, one that requires NADP + and one that requires NAD +
However, some benefits, such as enhanced detoxification and reduced oxidative stress, may take 4 to 6 weeks to fully manifest
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