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Such multifaceted benefits have expanded GLP-1RAs therapeutic scope to neurodegenerative, cardiovascular, and chronic kidney disease, etc

Glossary of Terms References Jastreboff AM, et al

Both incorporate glucagon receptor agonism alongside GLP-1 activity, but retatrutide takes this further by adding a third target -- GIP receptor agonism -- making it the first triple-hormone receptor agonist in clinical development

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