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These may include non-GLP-1 weight-management medications (such as phentermine-topiramate or bupropion-naltrexone), referral to bariatric surgery evaluation, or structured lifestyle programs without medication

Furthermore, the inhibition of the mTOR kinase protein complex mTORC1 in RSC96 cells promoted apoptosis by silencing PARTOR or RICTOR

The decision between Topiramate and Semaglutide for weight management depends on many factors, including your medical history, weight loss goals, age, lifestyle, other health conditions, and personal preferences

Our study did not collect data on time since diagnosis, which would have provided a more direct index of disease duration