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Although GLP-1 medications have transformed obesity treatment, there remains a significant need for rigorous data examining how these therapies affect fertility and reproductive function in this population. The RESTORE study is currently evaluating semaglutide treatment in girls and women with PMOS and obesity, with the overarching goal of determining whether weight loss and metabolic improvements can restore ovulation and improve reproductive outcomes

In accordance with the instructions of the manufacturer, the participants were thoroughly informed regarding the known adverse events of GLP-1RAs, including gastrointestinal events and anorexia, before the administration

Patients with wasting diseases such as HIV and AIDS

The LISA randomized trial of a weight loss intervention in postmenopausal breast cancer