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Conservative titration protocol: Providers begin patients at low doses and increase gradually based on individual tolerance and progress, not a one-size-fits-all schedule
Minimum Targets: Work with a nutritionist to establish appropriate calorie minimums that allow weight loss while maintaining adequate nutrition
In an overdose, a large amount of NAPQI is generated, which overwhelms the detoxification process and leads to liver cell damage
Acknowledgements The authors gratefully acknowledge the support of the National Institute of Dental and Craniofacial Research (NIDCR), and the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health, under award numbers UG3/UH3DE027695 to DSWB, CEO, and LAD, NIEHS Environmental Health Sciences Center T32 ES007026 to JAM, and F31 DE029658 to LRP
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