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As an NNMT inhibitor, it is associated with reduced white adipose tissue, improved NAD+ availability, and support for insulin sensitivity

Keith Lafferty MD, Fort Myers on October 10, 2025

Key benefits Why people compare it 1 Stimulates natural pulsatile GH release from anterior pituitary somatotrophs 2 Preserves physiological negative feedback via somatostatin and IGF-1 loops 3 Increases IGF-1 by 30-40% in GH-deficient adults over 6 months 4 Improves body composition: +3.2 kg lean mass, -2.8 kg fat mass in clinical trials 5 Enhances slow-wave sleep by approximately 25% in subjects over age 50 6 Previously FDA-approved as Geref for diagnostic and therapeutic use 7 Supports exercise capacity with measurable VO2 max improvements of 8-10% 8 Short plasma half-life (10-20 min) allows precise timing of GH pulse induction Deep research About Sermorelin Sermorelin, formally designated GRF(1-29)NH2, is a synthetic 29-amino-acid peptide corresponding to the first 29 residues of the 44-amino-acid human growth hormone-releasing hormone (GHRH)

Human side-effect rates and interaction risks are not established