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The spectrum and impact of metabolic dysfunction in MAFLD: a longitudinal cohort analysis of 32683 overweight and obese individuals

STEP 5: In adults with obesity or overweight with at least one weight-related comorbidity, along with diet and exercise, Significant weight loss that lasts with Wegovy 2.4 mg 3 Co-primary end point: Mean change in body weight (%) from week 0 to week 104 3 During the trial, 13% of patients in the Wegovy arm discontinued treatment compared with 27% in the placebo arm

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and the factors that influence bioavailability can be divided into physiological, physicochemical, and biopharmaceutical factors