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To determine if FXR1 influences GPX4 expression by binding to its 3UTR, two luciferase reporters were constructed: G3U-Luci containing the full-length 3UTR of GPX4, and G3U-Luci mut containing the 3UTR of GPX4 with the FXR1 recognition motif mutated (Figure 6H)
In a study involving more than 10,000 elderly individuals, long-term, high-dose NSAID therapy was associated with a significantly increased risk of progression of chronic kidney disease (Gooch 2007)
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