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Solvent-carrier risk: Vehicles such as DMSO are potent skin-penetration enhancers with their own irritation and contamination-shuttling risks
Carro E, Trejo JL, Busiguina S, Torres-Aleman I
Public awareness of the association between alcohol and cancer in the US
True irritation requiring product discontinuation presents as persistent burning or stinging lasting beyond application period, significant redness spreading beyond application zone or lasting multiple hours, swelling of eyelids or periorbital area, increased sensitivity making area uncomfortable to touch, or itching suggesting allergic response
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