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Side-by-Side Why the Percentages Are Not a Clean Ranking Different: Trial durations (48 vs 42 weeks primary stories) Populations and lifestyle run-ins Estimands and dose-selection strategies How much of the dose-response curve is public A 20% Phase 2 mean does not automatically "beat" a 10.7% Phase 2 mean for future labeled use Phase 3 discontinuation rates and real-world persistence often reorder the leaderboard

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