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Department of Health and Human Services Physical Activity Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity weekly, plus muscle-strengthening activities 2-3 days per week for overall health and weight management

17 The authors describe the potential of SSRIs to inhibit the analgesic activity of tramadol and codeine (via inhibition of their metabolic activation), causing serotonin syndrome with chronic use in the presence of high-dose tramadol therapy, which induces a synergistic serotonergic action

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"And if we're prescribing any medicine that could be contraindicated, we let them know," she said