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The causal role of gut microbiota in PCOS pathogenesis has been further substantiated by animal studies demonstrating that fecal microbiota transplantation from PCOS patients to healthy mice recapitulates core disease manifestations, including anovulation and metabolic dysfunction (20, 21)

In general, autophagy seems to play a protective role in the physiological and pathological cell processes and promote cell survival during various stress conditions

CYP3A4, CYP2D6, CYP1A2, and CYP2C9 are the primary isoforms, collectively metabolizing up to 80% of all pharmaceutical drugs (Annual Review of Pharmacology and Toxicology, 2018)

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