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Since GLP-1R has been localized by immunocytochemistry in mouse aortic smooth muscle cells, endothelial cells, monocytes, and macrophages, both direct and indirect actions of GLP-1 may contribute to the potential reduction of atherogenesis

Although Asp29Asn was unique to GD_SS1.2 evolution, Asn143Asp and Pro174Leu were present in both trajectories and likely contributed to increased substrate flexibility

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Biolo G, Toigo G, Ciocchi B, Situlin R, Iscra F, Gullo A, Guarnieri G: Metabolic response to injury and sepsis: changes in protein metabolism