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While our study does not establish causality or delineate mechanism, the consistency of associations across multiple SUD categories aligns with a shared neurobehavioral pathway influenced by GLP-1 receptor activation

Although the effects of tirzepatide and GIP-085 on the human GIPR were not assessed in the current study, comparable EC 50 values were observed in human adipocytes expressing the hGIPR ( 45 ), supporting the translational relevance of these findings

Instead of writing diabetes on an insurance claim form, a corresponding ICD-10 code, such as E11.9, is used instead

Clinicians should record baseline heart rate before initiating treatment and reassess at each follow-up appointment