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every 24 to 48 hours or after 1.5 to 2 litres of solution has infused (Saskatchewan Health Authority, 2018)

Additionally, the suppression of pro-inflammatory cytokines (e.g., TNF-, IL-6) and inflammatory pathways, including the blocking of NF-B activation [39, 91], contributes to the establishment of an anti-inflammatory environment that can mitigate oxidative stress and inflammation induced muscle protein catabolism, thereby supporting the preservation of SMM and functional capacity [40]

Manufacturers only need to demonstrate that their product is safe to consume

Research has shown this is a vagal feed-forward response, not triggered directly by stimulation to the GI tract