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During this window, substances applied to the skin surface can penetrate directly to the dermis at concentrations that approach injectable delivery
Secondary pigment changes or scarring may occur in darker skin tones or with repeated trauma
The gap reflects the different question each estimand asks, of which non-adherence is one component
2.1.3 Metformin Metformin, an FDA-approved antidiabetic agent, is broadly used every day for the first-line treatment of type 2 diabetes mellitus, even if its therapeutic action is still not well-defined
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