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A: Safety data in humans is limited

This complexity complicates the development of precise and effective therapies that can specifically modulate ferroptosis without disrupting other essential cellular processes

However, challenges remain, including fully defining ferroptosis regulation and addressing potential off-target effects of inducers

109,153 Accordingly, exposure of SW480 colorectal cancer cells to hypoxia resulted in an enrichment in mitochondria of SQR protein levels and H 2 S detoxification activity