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Furthermore, GLP-1RAs increase c-fos expression (a marker of neuronal activity) in the adrenal medulla, activate neurons involved in central autonomic control, and stimulate tyrosine hydroxylase transcription in brainstem catecholamine neurons (22)

Beyond these principal sites of GLP-1R action, lower-level receptor expression has been documented in several additional tissues, including the heart, kidney, lungs, and testis (Pyke et al., 2014

Regarding storage during travel: Ozempic multi-dose pens may be stored at room temperature (up to 86F) for up to 56 days after first use

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