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a Median (IQR)
At the time of the respective regulatory submissions, the EMA required an LOCF-based approach [36] whereas the FDA requested an MI approach [37]
Ghrelin - a hormone with multiple functions
Unlike ulcerative colitis, which is limited to the colonic mucosa, Crohns disease features skip lesions areas of diseased bowel separated by segments of normal-appearing tissue and may involve multiple layers of the intestinal wall, leading to fibrosis, stricture formation, and fistulization, as described by the Crohns & Colitis Foundation
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