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In the alpha cells of the islets, GLP-1 receptor activation suppresses glucagon secretion, a process mediated by somatostatin release from adjacent delta cells

GLP-1 medications are unsuitable for individuals with: A personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia type 2 (MEN 2) They should also be used with caution in patients with severe gastrointestinal disease

It also interacts with the F-actin cytoskeleton in fibroblasts, improving cell spreading and migration needed for wound closure

[15] These studies measured weight reduction after 72 weeks in 2,519 participants who received either 5, 10, or 15 mg of tirzepatide once weekly and 958 participants who received weekly placebo injections