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Because the needle goes directly into this fatty layer, it allows for a slow, sustained absorption of the substance

This, in turn, also decreases the risk of infections due to injections

Both approaches have logic behind them, and individual response varies

Systemic is defined as including a minimum of two distinct organ systems and may include: Urticaria Flushing Pruritus Angioedema Nasal congestion Nasal pruritus Wheezing Throat swelling Hoarseness Headache Hypotensive syncope Tachycardia Abdominal cramping Diarrhea Biochemical markers: Consensus-2 also includes a 20% plus 2 ng/ml increase in serum tryptase level from the individuals baseline, but extends to additional biochemical markers as well