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Neuronal migration and differentiation were impaired in GDI1 -null mice, while synaptic vesicle dynamics was also affected
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Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025
The FDA has approved mecasermin (Increlex) recombinant native IGF-1 for severe primary IGF-1 deficiency
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