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It is noteworthy that these subsets have significant differences in their sensitivity to oxidative stress: B1 and MZ B cells have high expression of key enzymes involved in lipid synthesis, such as acetyl-coenzyme A carboxylase (ACC) and fatty acid synthase (FASN), resulting in elevated levels of ROS in the cells, and are therefore highly dependent on GPX4 to maintain redox homeostasis (158)

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