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Of the intranasally challenged mice, 20% developed meningitis without bacteremia, and the authors found that the infection induced a decreased expression and a relocation of the junction protein N-cadherin in the olfactory epithelium, which connects the nasopharynx with the CNS
The effects of water volume and post-dose fasting on SNAC exposure in the dosing conditions trial are shown in Supplementary Figs
However, the estimates variability and degree of uncertainty are indicated by the broad confidence intervals, especially in the random effects model ( Figure 9 )
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