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Published 2022 Sep 6
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The mechanism is purely metabolic: increased energy expenditure , suppressed lipogenesis, and elevated NAD+ levels that activate sirtuins (SIRT1, SIRT3), the same longevity-associated enzymes targeted by caloric restriction
When ML models are trained on multi-country datasets using uniform preprocessing, cross-cohort transfer performance increases, suggesting the existence of resilient PD signatures but the need for large, standardized training sets [189]
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